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Hypokalemia in aki

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. . . . . Definition (NCI_CTCAE) A disorder characterized by laboratory test results that indicate a low concentration of potassium in the blood. Definition (MSH) Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. Definition: A serum potassium level < 3.5 mEq/L. Severe hypokalemia < 2.5 mEq/L. Epidemiology. Common electrolyte disorder - 20% of hospitalized patients; 10-40% of patients on thiazide diuretics (Rosen 2014) Causes. Renal Losses (diuretics, steroid use, DKA, hyperaldosteronism) Increased non-renal losses (vomiting, diarrhea, sweating). Hyperkalemia is a potentially life-threatening electrolyte abnormality [ 1, 2, 3 ]. Although there is no internationally agreed upon definition for hyperkalemia, the European Resuscitation Council defines hyperkalemia as a plasma level > 5.5 mmol/L and severe hyperkalemia as > 6.5 mmol/L [ 4 ].

Hypokalemia occurred in 9/25 (36%) of acute kidney injury with recovery, 2/9 (22%) of acute kidney injury without recovery, and 27/223 (12%) of no acute kidney injury (p = 0.014). Patients with acute kidney injury showed a late onset of hypokalemia compared with those without acute kidney injury (p = 0.001). . . . . . . .

. . . . . . Hypokalemia is serum potassium concentration < 3.5 mEq/L (< 3.5 mmol/L) caused by a deficit in total body potassium stores or abnormal movement of potassium into cells. The most common cause is excess loss from the kidneys or gastrointestinal tract. Clinical features include muscle weakness and polyuria; cardiac hyperexcitability may occur with severe hypokalemia. .

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